This article provides crucial clinical insights regarding the formation and management of vesicles (fluid-filled blisters) following cupping therapy, a skin response less common than ecchymosis but requiring proper clinical discernment. A case study involved a patient who developed multiple small, clear vesicles within 24 hours after moderate-to-strong stationary silicone cupping along the Bladder Meridian, which resolved spontaneously. Biomedically, vesicles are caused by excessive negative pressure that mechanically separates the epidermal and dermal layers, leading to the accumulation of plasma and lymphatic fluid. From a Traditional Chinese Medicine (TCM) viewpoint, this phenomenon might signify the successful externalization of dampness or toxic heat, or alternatively, indicate that the treatment intensity surpassed the patient's constitutional tolerance. Practitioners should counsel patients beforehand to mitigate anxiety. Key risk factors include high negative pressure, prolonged retention time, and sensitive skin. Management protocols prioritize maintaining skin integrity, advising patients not to rupture the blisters, monitoring for secondary infection, and adjusting subsequent treatments by reducing pressure or duration.