This intriguing article proposes that the biting patterns of female mosquitoes may not be random but could, in fact, provide an observable biological demonstration of the subtle energy maps, or meridians, long recorded in East Asian medicine. The author suggests that mosquitoes, driven by evolutionary precision, seek not only blood but also qi—the vital energy of the body. Mosquitoes are known to be attracted to biochemical markers of energy and metabolism, specifically relying on ATP (adenosine triphosphate) as a phagostimulant to initiate feeding. This concept is linked to modern research showing physiological correlates for meridians and acupoints. Studies indicate that acupoints have high concentrations of mast cells, which release ATP upon stimulation, and elevated levels of ATP and CO2 are found along meridians, suggesting high metabolic activity. A chemical analogy is drawn between the TCM concept of zhen qi (air and food energy) and the formula for cellular respiration (producing ATP and CO2). The hypothesis suggests that when a mosquito bites, it inadvertently stimulates these mast cell clusters along the meridians, releasing the very ATP that encourages feeding. If this is the case, mosquito bite patterns are selective, guided by the biochemical signatures of qi. Further research correlating bite distribution with acupuncture meridians could help illuminate the material basis of qi.