This episode details significant clinical research evaluating electroacupuncture for the management of knee osteoarthritis. Reviewing a rigorous multicentre, randomized controlled trial published in eClinicalMedicine, the discussion covers findings from 480 adult participants with moderate knee osteoarthritis treated across six hospital sites. Participants received either targeted electroacupuncture or nonpenetrating sham treatments three times weekly over six weeks, utilizing key points including Xuehai, Liangqiu, Dubi, Neixiyan, Zusanli, Yanglingquan, Sanyinjiao, and Xuanzhong alongside continuous and sparse-dense wave electrical stimulation. The electroacupuncture cohort demonstrated remarkably superior, clinically meaningful reductions in WOMAC global scores, pain, and functional impairment, with advantages maintained throughout a 30-week follow-up period. Additionally, exploratory baseline and week-six MRI evaluations revealed notable reductions in infrapatellar fat-pad signal intensity and effusion-synovitis depth, indicating reduced local joint inflammation. While preliminary structural cartilage changes warrant extended investigation, the comprehensive clinical protocol provides clear, evidence-based parameters regarding needle depth, de qi elicitation, and frequency settings to maximize non-pharmacological arthritis care.