Chronic Fatigue Syndrome (CFS) is a debilitating condition marked by persistent fatigue and autonomic dysfunction. While conventional treatments focus on symptom relief, a recent randomized controlled trial explored how acupuncture and moxibustion could specifically modulate autonomic function. The study involved 210 participants, primarily those with CFS associated with qi deficiency syndrome, and healthy controls. Participants received either acupuncture at specific points like ST 36 (Zusanli) and CV 4 (Guanyuan), sham acupuncture, or moxibustion over 10 sessions.

The findings were significant: both acupuncture and moxibustion improved heart rate variability (HRV) and reduced fatigue in CFS patients. Acupuncture, particularly at ST 36, showed strong short-term effects by enhancing parasympathetic activity. Moxibustion offered long-term autonomic benefits, suggesting complementary mechanisms. Stimulating both ST 36 and CV 4 simultaneously provided the most substantial autonomic regulation, outperforming single-point treatments. This research highlights the value of these therapies for managing CFS symptoms and suggests tailoring treatments for personalized, mechanism-based interventions.